Descriptions:
Develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations.
Act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.
Develop QSP platform models for multiple oncology mechanisms including:
Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
Antibody-drug conjugates across lung, ovarian, and colorectal cancers
T-cell engagers and bispecifics/trispecifics in multiple myeloma
CAR-T therapies in hematologic malignancies
Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group
Qualifications:
PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development
Proven scientific track record and practical experience in several of the following areas
Statistical modeling
Modeling with differential equations
Scripting languages (R, Matlab, Python)
Drug development
Critical thinking and self-reflective
Persistent and resilient
Ability to connect unrelated concept and to generate original or unique ideas
Fluency in English required, German would be a plus
Benefits:
Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.
Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.
Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.
Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.
Synectics is an equal opportunity employer.